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Introduction: Carcinoma of the gallbladder is the most common malignancy of the biliary tract and the third most common gastrointestinal malignancy in and around the Northern region of India. Owing to its nonspecific symptoms, gallbladder carcinoma is generally diagnosed late in the disease course, but if a patient with gallstones experiences a sudden change of symptoms, then a cancer diagnosis should be considered. There are several factors which is associated with gallbladder malignancy such as gallstone, porcelain gallbladder, obesity, gallbladder polyps, gender, family history of gallbladder cancer and several carcinogens (chemicals). Objective: Objective of the study was to evaluate the different risk factor associated with gallbladder malignancy. It is an important to assess the risk factor for gall bladder malignancy take into account the confounding effect of gallstone. Materials and Methods: This prospective study carried out on 115 patients having evidence of gallbladder malignancy. The diagnosis was made accordance of sign and symptom, abdominal ultrasonography (USG) and a computed tomography (CT) scan of the abdomen, and was confirmed by histology. Results: Gallstone (83.5%) was the major risk factor for malignancy followed by Choledochal cysts (73%), use of tobacco (71.3%), Primary sclerosing cholangitis (36.5%), porcelain gallbladder (29.6%), obesity (24.3%), family history (23.5%), alcohol (20.9%), Gallbladder polyps (13.9%), bile duct abnormality (7.8%) and infection with typhoid (4.3%). The female were more susceptible to gallbladder bladder cancer the male female ratio was (1:2.7).