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Swaziland has the highest human immunodeficiency virus (HIV) and the acquired immunodeficiency syndrome (AIDS) prevalence in the world. The purpose of the study was to assess the learning needs of nurses in relation to care of people living with HIV and AIDS in Swaziland. In addition, identify preferred teaching-learning strategies for meeting the learning needs. This was a descriptive exploratory survey. The sample comprised 120 participants, from the four (4) regions of Swaziland. The participants completed a self-administered questionnaire. Descriptive statistics were used in analysing the data. The study findings revealed four (4) priority learning needs: HIV and AIDS prevention and control; care and support; coping and counselling; and HIV progression to AIDS. Discussion was reported as the most preferred reaching-learning strategy.